Ursula Hinz/Heribert Mohr

Stem cell-derived exosomes, therapeutic interventions, and anti-aging

Stem cell-derived extracellular vesicles (EVs), which cover both microvesicles (MV) and exosomes are increasingly in focus for application as an alternative or substitute in cellular therapy. Experimentally it has been documented that EVs are involved in cell-to-cell communication, cell signaling, and altering cell or tissue metabolism at short or long distances in the organism. It has been observed that MVs and exosomes influence the tissue responses to injury, infection, and disease. Stem cell-derived exosomes have content that includes cytokines, growth factors, signaling lipids, mRNAs, and regulatory miRNAs. The exosome’s materials are not static, but rather a product of the tissue origin, its activities, and the immediate intercellular neighbours of the stem cells. Consequently, there is a growing interest in the clinical applications of exosomes. Exosomes can potentially be used for prognosis, therapy, and biomarkers for health, disease, and anti-aging. Exosomes offer the chance for cell-free regenerative medicine with decreased risk. In their way to the clinic much will depend on the quality, reproducibility, modifications, cargoing of therapeutic substances, and potency of their production, in the same manner, that these parameters influenced the development of cell-based therapies. is also essential to better understand the manifestation of testicular cancer for the development of improved and more individualized diagnostic- and therapy options in the future. At a present stage the scientific knowledge about testicular genes and proteins in the human is still insufficiently characterized in terms of cell type specific localization and function. The establishment of a more testis specific molecular atlas would be significant for the organization of our knowledge and the increase of molecular understanding of human reproductive biology and disease


Ursula Hinz
Tel.: 06221 - 54-8306
E-Mail: ursula.hinz@urz.uni-heidelberg.de

Verantwortlich: E-Mail,   Letzte Änderung: Mon, 25.11.2019
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