Rui Chen


Anatomie und Zellbiologie
Im Neuenheimer Feld 307
69120 Heidelberg
Tel. 06221-54-8697
Email


Rui project

Tendon regeneration with stem cells

In adults, the healing tendon generates fibrovascular scar tissue and thus never histologically, mechanically and functionally recovers manifesting in chronic and degenerative diseases. The processes and mechanisms of tendon development, fetal regeneration in comparison to adult defect repair and degenerating are guiding generative therapeutic options. The application of stem cells, growth factors, transcription factors, and gene therapy in tendon injury therapies to intervene in the scarring process and to induce functional regeneration of the lesioned tissue is of major importance. We investigate future therapeutic approaches for tendon injuries involving molecular embryology, transgenic mouse models and stem cell technologies.

References

1: Conrad S, Weber K, Walliser U, Geburek F, Skutella T. Stem Cell Therapy for Tendon Regeneration: Current Status and Future Directions. Adv Exp Med Biol. 2018 Jul 25. doi: 10.1007/5584_2018_194. [Epub ahead of print] PubMed PMID: 30043235.

2: Geburek F, Roggel F, van Schie HTM, Beineke A, Estrada R, Weber K, Hellige M, Rohn K, Jagodzinski M, Welke B, Hurschler C, Conrad S, Skutella T, van de Lest C, van Weeren R, Stadler PM. Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells: a controlled experimental trial. Stem Cell Res Ther. 2017 Jun 5;8(1):129. doi: 10.1186/s13287-017-0564-8. PubMed PMID: 28583184; PubMed Central PMCID: PMC5460527.

3: Geburek F, Mundle K, Conrad S, Hellige M, Walliser U, van Schie HT, van Weeren R, Skutella T, Stadler PM. Tracking of autologous adipose tissue-derived mesenchymal stromal cells with in vivo magnetic resonance imaging and histology after intralesional treatment of artificial equine tendon lesions--a pilot study. Stem Cell Res Ther. 2016 Feb 1;7:21. doi: 10.1186/s13287-016-0281-8. PubMed PMID: 26830812; PubMed Central PMCID: PMC4736260.

4: Conze P, van Schie HT, van Weeren R, Staszyk C, Conrad S, Skutella T, Hopster K, Rohn K, Stadler P, Geburek F. Effect of autologous adipose tissue-derived mesenchymal stem cells on neovascularization of artificial equine tendon lesions. Regen Med. 2014;9(6):743-57. doi: 10.2217/rme.14.55. PubMed PMID: 25431911.














Verantwortlich: E-Mail,   Letzte Änderung: Mon, 29.06.2020
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