Kontakt

Dr. Femke L. Groeneweg

Gruppenleiterin


Anatomie und Zellbiologie
Im Neuenheimer Feld 307
69120 Heidelberg
Tel. 06221-548687
Fax 06221-544952
Email


Gruppe Groeneweg

Research Summary

Plasticity of Inhibitory Synapses

The activity of a neuron is tightly regulated by the balance between its excitatory and inhibitory inputs. As both types of synapses are continually being formed and deleted throughout life this suggests that also their structural components need to remain highly plastic and responsive to environmental changes. Within inhibitory postsynaptic membrane specializations, the scaffolding protein Gephyrin is the main structural component. It is thought to form a 3D-lattice onto which GABAA receptors, glycine receptors, as well as many more synaptic components, can dock. As one would expect, Gephyrin itself is also heavily regulated.


I am interested in the regulation of Gephyrin’s subcellular localization. In multiple research lines I am studying its regulation by common kinases, for example CDK5, and its associations with the cytoskeleton. My research focuses heavily on primary neuronal cultures and confocal imaging. Both on fixed tissue and life imaging of Gephyrin’s real-time dynamics.

Students interested in doing an internship in the group are very welcome to contact me.

Phosphorylated Gephyrin (in green) colocalized with a marker of the presynaptic nerve terminals (VGAT in red).


 

Group Leader

Dr. Femke L. Groeneweg

Group Members

Karin Rummer (Technical Assistant)




Verantwortlich: E-Mail,   Letzte Änderung: Wed, 11.04.2018
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