Kontakt

Dr.
Christoph Körber

Gruppenleiter


Anatomie und Zellbiologie
Im Neuenheimer Feld 307
69120 Heidelberg
Tel. 06221 54 8391
Fax: 06221 54 4951
Email


Gruppe Körber

Research summary

Mechanisms of high frequency neurotransmission

Signal processing in the auditory system, particular the auditory brainstem, relies on high fidelity, high frequency neurotransmission. Individual signal cues need to be reliably transferred between individual nuclei of the auditory brainstem at high frequency in order to ensure proper extraction and interpretation of auditory information. We are trying to understand the molecular mechanisms that enable these neurons to faithfully transmit high frequency information and that are disrupted in various forms of hearing loss. We are especially interested in specializations of the presynaptic compartments of these neurons that allow them to release neurotransmitter at high frequencies over a long period of time. As a model system, we use the calyx of Held synapse, a giant presynaptic terminal in the auditory brainstem that contains several hundred sites for neurotransmitter release, so called active zones. Due to its size, the calyx of Held is amenable to presynaptic patchclamp recordings, allowing us to perform detailed studies on presynaptic mechanisms of high frequency neurotransmission. In our lab we apply various experimental approaches including molecular biology, viral gene transfer, fluorescence microscopy, state-of-the-art electrophysiology, super resolution microscopy, electronmicroscopy and single cell gene expression profiling.



Group Leader

Dr. Christoph Körber

Current funding

DFG SFB 1134 "Neuronal Ensembles" TP A4
DFG SPP 1608 "Ultrafast and temporally precise information processing: normal and dysfunctional hearing"
Excellence initiative Frontiers 2014 "Single cell expression profiling using nCounter"



Group Members

Helia Saber        Doktorandin
Marion Schmitt   TA







Verantwortlich: E-Mail,   Letzte Änderung: Tue, 25.04.2017
zum Seitenanfang/up