PD Dr. Stephan Heermann

Research interests

Molecular mechanisms regulating optic fissure closure

The optic fissure is a gap between the nasal and temporal retinal parts on the ventral side of the vertebrate eye. This gap is used as a transport route during development and should be closed by fusion later on. A failure of optic fissure closure with a remaining gap is referred to as coloboma. Although a gene coloboma network was proposed, and many genes are linked to coloboma formation, the process of optic fissure closure is still not well understood. In this project we are searching for effector molecules mediating fissure closure.

We are open for collaborations. Please get in touch with me.

Interested students, please also get in touch with me.

Further projects

In the past we investigated the development of murine Schwann-Cells with the help of time-lapse imaging. The system we used for this was the superior cervical ganglion (SCG) of the sympathetic chain. In parallel we also addressed the development of the sympathetic precursors within the ganglia, especially in the period when the precursors were not yet dependent on the target derived NGF.

In the future I want to address the establishment of the sympathetic chain in zebrafish and Medaka. The use of these model systems will enable us to study the process with time-lapse microscopy in vivo.

Interested students please get in touch with me.

 

Group Leader
PD Dr. Stephan Heermann

 

Goup Members

Priska Eckert, Bsc (Masterstudent)
Karin Rummer (Technician)
Nicola Gärtner (Technician Azubi)

 

 

 

 

 

 

 

 

Verantwortlich: E-Mail,   Letzte Änderung: Fri, 20.04.2018
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